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해외논문/특허 | MSM 관련 논문 - 염증 억제 관련

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작성자 지니케어 작성일17-01-26 01:34 조회9,981회 댓글0건

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Methylsulfonylmethane inhibits NLRP3 inflammasome activation.​

Cytokine. 2015 Feb;71(2):223-31. doi: 10.1016/j.cyto.2014.11.001. Epub 2014 Nov 21.

Ahn H1, Kim J1, Lee MJ1, Kim YJ2, Cho YW3, Lee GS4.​

Abstract

Methylsulfonylmethane (MSM) is an organosulfur compound and the health benefits associated with MSM include inflammation. Although MSM has been shown to have various physiological effects, no study has yet focused on inflammasome activation. The inflammasome is a multiprotein complex that serves as a platform for caspase 1-dependent proteolytic maturation and secretion of interleukin-1β (IL-1β). In this study, we tested the effect of MSM on inflammasome activation using mouse and human macrophages. In our results, MSM significantly attenuated NLRP3 inflammasome activation in lipopolysaccharide-primed macrophages, although it had no effect on NLCR4 or AIM2 inflammasome activation. Extracts of MSM-enriched vegetables presented the same inhibitory effect on NLRP3 inflammasome activation as MSM. MSM also attenuated the transcriptional expression of IL-1α, IL-1β, IL-6, and NLRP3. Taken together, these results show that MSM has anti-inflammatory characteristics, interrupts NLRP3 inflammasome activation, and inhibits pro-cytokine expression. We further confirmed the intracellular mechanism of MSM in relation to NLRP3 inflammasome activation, followed by comparison with that of DMSO. Both chemicals showed a synergic effect on anti-NLRP3 activation and attenuated production of mitochondrial reactive oxygen species (ROS). Thus, MSM is a selective inhibitor of NLRP3 inflammasome activation and can be developed as a supplement to control several metabolic disorders.

Copyright © 2014 Elsevier Ltd. All rights reserved.

간략 내용은 염증에 좋은 MSM은 ​여러 분야의 생리적인 효과를 보여주었으나 염증 관련 복합단백질체 활성와에 관점을 둔 연구는 없었다.

없어서 아마 이 연구를 한 모양이네요.

결론은 염증관련 복합단백질체의 활성화를 방해하고 관련 단백질의 발현을 방해했다는 내용입니다.

염증을 일으키는 단백질체의 발현을​ 억제시켰다는 뜻이네요. 그런건 열심히 방해해줘도 좋을 듯. ^^

google에서 제목으로 검색을 하시면 논문 내용이 나옵니다. 염증관련 논문으로 번역보기로 보시면 어떤 내용인지 보실 수 있습니다.

https://translate.google.co.kr/translate?hl=ko&sl=en&u=https://www.ncbi.nlm.nih.gov/pubmed/25461402&prev=search

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